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Shear stress-responsive polymersome nanoreactors inspired by the marine bioluminescence of dinoflagellates

  • Rifaie‐Graham, Omar Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland - Current address: Department of Materials and Department of Bioengineering Institute of Biomedical Engineering Imperial College London Exhibition Road London SW7 2AZ UK
  • Galensowske, Nikolas F. B. Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland
  • Dean, Charlie Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland
  • Pollard, Jonas Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland
  • Balog, Sandor Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland
  • Gouveia, Micael G. Department of Pure and Applied Chemistry University of Strathclyde Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK
  • Chami, Mohamed Bio, EM lab Center of Cellular Imaging and Nano, Analytics (C-CINA) Biozentrum University of Basel Mattenstrasse 26 4058 Basel Switzerland
  • Vian, Antoine Soft Materials Laboratory Institute of Materials École Polytechnique Fédérale de Lausanne, EPFL-STI-IMX-SMAL MXC 231 Station 12 1015 Lausanne Switzerland
  • Amstad, Esther Soft Materials Laboratory Institute of Materials École Polytechnique Fédérale de Lausanne, EPFL-STI-IMX-SMAL MXC 231 Station 12 1015 Lausanne Switzerland
  • Lattuada, Marco Department of Chemistry University of Fribourg Chemin du Musée 9 1700 Fribourg Switzerland
  • Bruns, Nico Adolphe Merkle Institute University of Fribourg Chemin des Verdiers 4 1700 Fribourg Switzerland - Department of Pure and Applied Chemistry University of Strathclyde Thomas Graham Building, 295 Cathedral Street Glasgow G1 1XL UK
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    2020
Published in:
  • Angewandte Chemie International Edition. - 2020, vol. 60, no. 2, p. 904-909
English Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction compartments, is transferred to polymer-based nanoreactors. Amphiphilic block copolymers that carry nucleobases in their hydrophobic block are self-assembled into polymersomes. The membrane of the vesicles can be transiently switched between an impermeable and a semipermeable state by shear forces occurring in flow or during turbulent mixing of polymersome dispersions. Nucleobase pairs in the hydrophobic leaflet separate when mechanical force is applied, exposing their hydrogen bonding motifs and therefore making the membrane less hydrophobic and more permeable for water soluble compounds. This polarity switch is used to release payload of the polymersomes on demand, and to activate biocatalytic reactions in the interior of the polymersomes.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309188
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