Corona Immunitas: study protocol of a nationwide program of SARS-CoV-2 seroprevalence and seroepidemiologic studies in Switzerland
West, Erin A.Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland
Anker, DanielaPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland
Amati, RebeccaInstitute of Public Health, Università Della Svizzera Italiana, Lugano, Switzerland
Richard, AudeUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland - Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Wisniak, AniaUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland - Institute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Butty, AudreyCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Albanese, EmilianoInstitute of Public Health, Università Della Svizzera Italiana, Lugano, Switzerland
Bochud, MurielleCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Chiolero, ArnaudPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland - Institute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
Crivelli, LucaInstitute of Public Health, Università Della Svizzera Italiana, Lugano, Switzerland
Cullati, StéphanePopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland
d'Acremont, ValérieCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Epure, Adina MihaelaPopulation Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland - Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Fehr, JanEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland
Flahault, AntoineInstitute of Global Health, Faculty of Medicine, University of Geneva, Geneva, Switzerland
Fornerod, LucHealth Observatory of Valais, Sion, Switzerland
Frank, IrèneClinical Trial Unit, Cantonal Hospital Luzern, Luzern, Switzerland
Frei, AnjaEpidemiology, Biostatistics and Prevention Institute, University of Zurich, Hirschengraben 84, 8001, Zurich, Switzerland
Michel, GiselaDepartment of Health Sciences and Medicine, University of Luzern, Luzern, Switzerland
Gonseth, SemiraCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Guessous, IdrisUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland
Imboden, MedeaSwiss Tropical and Public Health Institute, Basel, Switzerland
Kahlert, Christian R.Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland
Kaufmann, LaurentService de La Santé Publique, Canton de Neuchâtel, Neuchâtel, Switzerland
Kohler, PhilippDepartment of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland
Mösli, NicolaiSwiss Tropical and Public Health Institute, Basel, Switzerland
Paris, DanielSwiss Tropical and Public Health Institute, Basel, Switzerland
Rodondi, NicolasInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland
Stringhini, SilviaUnit of Population Epidemiology, Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland - Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland
Vermes, ThomasSwiss Tropical and Public Health Institute, Basel, Switzerland
Vollrath, FabianCorona Immunitas Program Management Group, Swiss School of Public Health, Zurich, Switzerland
English
Objectives Seroprevalence studies to assess the spread of SARS-CoV-2 infection in the general population and subgroups are key for evaluating mitigation and vaccination policies and for understanding the spread of the disease both on the national level and for comparison with the international community. Methods Corona Immunitas is a research program of coordinated, population-based, seroprevalence studies implemented by Swiss School of Public Health (SSPH+). Over 28,340 participants, randomly selected and age-stratified, with some regional specificities will be included. Additional studies in vulnerable and highly exposed subpopulations are also planned. The studies will assess population immunological status during the pandemic. Results Phase one (first wave of pandemic) estimates from Geneva showed a steady increase in seroprevalence up to 10.8% (95% CI 8.2–13.9, n = 775) by May 9, 2020. Since June, Zurich, Lausanne, Basel City/Land, Ticino, and Fribourg recruited a total of 5973 participants for phase two thus far. Conclusions Corona Immunitas will generate reliable, comparable, and high-quality serological and epidemiological data with extensive coverage of Switzerland and of several subpopulations, informing health policies and decision making in both economic and societal sectors. ISRCTN Registry: https://www.isrctn.com/ISRCTN18181860