Journal article

A twist in the ABC : regulation of ABC transporter trafficking and transport by FK506‐binding proteins

  • Geisler, Markus Department of Biology University of Fribourg Switzerland
  • Hegedűs, Tamás Department of Biophysics and Radiation Biology Semmelweis University Budapest Hungary
Published in:
  • FEBS Letters. - 2020, vol. 594, no. 23, p. 3986-4000
English Post-transcriptional regulation of ATP-binding cassette (ABC) proteins has been so far shown to encompass protein phosphorylation, maturation, and ubiquitination. Yet, recent accumulating evidence implicates FK506-binding proteins (FKBPs), a type of peptidylprolyl cis–trans isomerase (PPIase) proteins, in ABC transporter regulation. In this perspective article, we summarize current knowledge on ABC transporter regulation by FKBPs, which seems to be conserved over kingdoms and ABC subfamilies. We uncover striking functional similarities but also differences between regulatory FKBP-ABC modules in plants and mammals. We dissect a PPIase- and HSP90-dependent and independent impact of FKBPs on ABC biogenesis and transport activity. We propose and discuss a putative new mode of transient ABC transporter regulation by cis–trans isomerization of X-prolyl bonds.
Faculté des sciences et de médecine
Département de Biologie
  • English
Biological sciences
License undefined
Persistent URL

Document views: 32 File downloads:
  • gei_tar.pdf: 89