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Journal article

G-quadruplex based biosensor: A potential tool for SARS-CoV-2 detection

  • Xi, Hui College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China
  • Juhas, Mario Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland
  • Zhang, Yang College of Science, Harbin Institute of Technology (Shenzhen), Shenzhen, Guangdong, 518055, China
    01.11.2020
Published in:
  • Biosensors and Bioelectronics. - 2020, vol. 167, p. 112494
English G-quadruplex is a non-canonical nucleic acid structure formed by the folding of guanine rich DNA or RNA. The conformation and function of G-quadruplex are determined by a number of factors, including the number and polarity of nucleotide strands, the type of cations and the binding targets. Recent studies led to the discovery of additional advantageous attributes of G-quadruplex with the potential to be used in novel biosensors, such as improved ligand binding and unique folding properties. G-quadruplex based biosensor can detect various substances, such as metal ions, organic macromolecules, proteins and nucleic acids with improved affinity and specificity compared to standard biosensors. The recently developed G- quadruplex based biosensors include electrochemical and optical biosensors. A novel G-quadruplex based biosensors also show better performance and broader applications in the detection of a wide spectrum of pathogens, including SARS-CoV-2, the causative agent of COVID-19 disease. This review highlights the latest developments in the field of G-quadruplex based biosensors, with particular focus on the G-quadruplex sequences and recent applications and the potential of G- quadruplex based biosensors in SARS-CoV-2 detection.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/309033
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