Journal article

Variable interhemispheric asymmetry in layer v of the supplementary motor area following cervical hemisection in adult macaque monkeys

  • Contestabile, Alessandro Department of Basic Neuroscience, University of Geneva
  • Colangiulo, R. Department of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland
  • Lucchini, Matteo Department of Basic Neuroscience, University of Geneva
  • Rouiller, Eric M. Department of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland
  • Schmidlin, Eric Department of Neurosciences and Movement Sciences, Section of Medicine, Faculty of Sciences and Medicine, Fribourg Center of Cognition, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland
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    01.09.2020
Published in:
  • eNeuro. - 2020, vol. 7, no. 5, p. ENEURO.0280-20.2020
English Motor cortical areas from both hemispheres play a role during functional recovery after a unilateral spinal cord injury (SCI). However, little is known about the morphologic and phenotypical differences that a SCI could trigger in corticospinal (CS) neurons of the ipsilesional and contralesional hemisphere. Using an SMI-32 antibody which specifically labeled pyramidal neurons in cortical Layers V, we investigated the impact of a unilateral cervical cord lesion on the rostral part (F6) and caudal part (F3) of the supplementary motor area (SMA) in both hemispheres of eight adult macaque monkeys compared with four intact control monkeys. We observed in F3 (but not in F6) interindividual variable and adaptive interhemispheric asymmetries of SMI-32- positive Layer V neuronal density and dendritic arborization, which are strongly correlated with the extent of the SCI as well as the duration of functional recovery, but not with the extent (percentage) of functional recovery.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/309030
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