Journal article

Phosphorylation and circadian molecular timing

  • Brenna, Andrea Department of Medicine, University of Fribourg, Fribourg, Switzerland - Department of Biology, University of Fribourg, Fribourg, Switzerland
  • Albrecht, Urs Department of Biology, University of Fribourg, Fribourg, Switzerland
  • 26.11.2020
Published in:
  • Frontiers in Physiology. - 2020, vol. 11, p. 612510
English Endogenous circadian rhythms are biological processes generated by an internal body clock. They are self-sustaining, and they govern biochemical and physiological processes. However, circadian rhythms are influenced by many external stimuli to reprogram the phase in response to environmental change. Through their adaptability to environmental changes, they synchronize physiological responses to environmental challenges that occur within a sidereal day. The precision of this circadian system is assured by many post-translational modifications (PTMs) that occur on the protein components of the circadian clock mechanism. The most ancient example of circadian rhythmicity driven by phosphorylation of clock proteins was observed in cyanobacteria. The influence of phosphorylation on the circadian system is observed through different kingdoms, from plants to humans. Here, we discuss how phosphorylation modulates the mammalian circadian clock, and we give a detailed overview of the most critical discoveries in the field.
Faculté des sciences et de médecine
Département de Biologie, Département de Médecine
  • English
Biological sciences
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