Journal article

Wide spread of carbapenemase-producing bacterial isolates in a Nigerian environment

  • Terrier, Christophe Le Medical and Molecular Microbiology, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Masseron, Amandine Medical and Molecular Microbiology, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Uwaezuoke, Nkolika Stella Department of Medical Microbiology and Parasitology, National Hospital Abuja, Abuja, Nigeria
  • P.Edwin, Chinagozi Dept of Medical Microbiology & Parasitology, Aminu Kano Teaching, Hospital, Kano, Nigeria
  • E.Ekuma, Agantem Department of Medical Microbiology, University of Calabar Teaching Hospital, Calabar, Nigeria
  • Olugbeminiyi, Folake Department of Medical Microbiology, National Orthopaedic Hospital, Igbobi, Lagos, Nigeria
  • Shettima, Shuwaram Department of Medical Microbiology, Federal Medical Center, Yola, Nigeria
  • Ushie, Simon Department of Medical Microbiology & Parasitology, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria
  • Poirel, Laurent Medical and Molecular Microbiology, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland
  • Nordmann, Patrice Medical and Molecular Microbiology, Section of Medicine, Faculty of Science and Medicine, University of Fribourg, Switzerland - INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland
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    01.06.2020
Published in:
  • Journal of Global Antimicrobial Resistance. - 2020, vol. 21, p. 321–323
English Objectives: The presence of carbapenemase-producing bacterial isolates is found not only in hospital and community settings but also in the environment. Carbapenemase production may be related to acquired, usually plasmid-borne, β-lactamase genes or to chromosomal genes intrinsic to various species. The aim of this study was to evaluate the occurrence of such carbapenemase-producing bacterial isolates among environmental samples from Nigeria.Methods: A total of 122 environmental samples were plated on carbapenem-containing media. A total of 259 isolates were recovered, among which 124 were carbapenemase-producers according to the results of the Rapidec® Carba NP test.Results: The majority of isolates (n=112) recovered corresponded to natural producers of carbapenemases, i.e. Stenotrophomonas maltophilia (n=108), Burkholderia cepacia (n=1), Shewanella sp. (n=1), Sphingobacterium sp. (n=1) and Chryseobacterium gleum (n=1). Ten isolates (mainly Enterobacteriaceae and Acinetobacter baumannii) produced an acquired carbapenemase, most commonly of the NDM type. In addition, two Pseudomonas otitidis isolates were identified as producing the Ambler class B carbapenemase POM-1, further confirming that this carbapenemase is naturally produced in this environmental species. Finally, several isolates co-producing 16S rRNA methylases (ArmA, RmtC) and/or extended-spectrum β-lactamases (CTX-M-9, CTX-M-15) were also identified.Conclusion: This study revealed the presence and diversity of clinically- relevant antimicrobial-resistant bacteria in the environment in Nigeria.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308889
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