Study protocol for the ABERRANT study: antibiotic-induced disruption of the maternal and infant microbiome and adverse health outcomes — a prospective cohort study among children born at term
- Volery, Maryse Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland
- Scherz, Valentin Institute of Microbiology, Lausanne University Hospital, Lausanne, Switzerland - Facultiy of Medicine, University of Lausanne, Lausanne, Switzerland
- Jakob, William Microbiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland
- Bandeira, Diane Microbiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland
- Deggim-Messmer, Vanessa Microbiology Laboratory, Fribourg Hospital HFR, Fribourg, Switzerland
- Lauber-Biason, Anna Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland
- Wildhaber, Johannes Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland
- Falquet, Laurent Department of Biology, University of Fribourg, Fribourg, Switzerland - Swiss Institute of Bioinformatics, Lausanne, Switzerland
- Curtis, Nigel Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia - Infectious Diseases Research Group, Murdoch Children’s Research Institute, Parkville, Victoria, Australia - Infectious Diseases Unit, The Royal Children’s Hospital Melbourne, Parkville, Victoria, Australia
- Zimmermann, Petra Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland - Department of Paediatrics, Fribourg Hospital HFR, Fribourg, Switzerland - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia - Infectious Diseases Research Group, Murdoch Children’s Research Institute, Parkville, Victoria, Australia
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01.06.2020
Published in:
- BMJ Open. - 2020, vol. 10, no. 6, p. e036275
English
Introduction: There is compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Antibiotics cause profound changes in the microbiome. However, the effect of intrapartum and early-life antibiotics on the maternal intestinal and breast milk microbiome, and the infant oral and intestinal microbiome, and whether effects are only short term or persist long term remain uncertain. Methods and analyses: In this prospective cohort study, we will use metagenomic sequencing to determine: (1) the effect of intrapartum antibiotics on the composition of the breast milk, and the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (2) the effect of antibiotic exposure in the first year of life on the composition of the infant oral and intestinal microbiome, including the development and persistence of antibiotic resistance; (3) the effect of disruption of the infant oral and intestinal microbiome on health outcomes and (4) the compositional overlap between the maternal intestinal microbiome, the breast milk microbiome and the infant oral and intestinal microbiome. Ethics and dissemination: The ABERRANT study has been approved by the commission cantonale d’éthique de la recherche sur l’être humain (CER-VD) du Canton de Vaud (#2019–01567). Outcomes will be disseminated through publication and will be presented at scientific conferences. Trial registration number NCT04091282.
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine 3ème année, Master en médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 328649
- DOI 10.1136/bmjopen-2019-036275
- Persistent URL
- https://folia.unifr.ch/unifr/documents/308785
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