Journal article

From zero to six double bonds: phospholipid unsaturation and organelle function

  • Antonny, Bruno Institut de Pharmacologie Moléculaire et Cellulaire, Université de Nice Sophia Antipolis and Centre National de la Recherche Scientifique (CNRS), Valbonne, France
  • Vanni, Stefano Department of Biology, University of Fribourg, Switzerland
  • Shindou, Hideo Department of Lipid Signaling, Research Institute, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan
  • Thierry, Ferreira Laboratoire Signalisation et Transports Ioniques Membranaires (STIM), CNRS ERL 7368, Université de Poitiers, France
Show more…
    01.07.2015
Published in:
  • Trends in Cell Biology. - 2015, vol. 25, no. 7, p. 427–436
English Cellular phospholipids (PLs) differ by the nature of their polar heads as well as by the length and unsaturation level of their fatty acyl chains. We discuss how the ratio between saturated, monounsaturated, and polyunsaturated PLs impacts on the functions of such organelles as the endoplasmic reticulum, synaptic vesicles, and photoreceptor discs. Recent experiments and simulations suggest that polyunsaturated PLs respond differently to mechanical stress, including membrane bending, than monounsaturated PLs owing to their unique conformational plasticity. These findings suggest a rationale for PL acyl chain remodeling by acyltransferases and a molecular explanation for the importance of a balanced fatty acid diet.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308762
Statistics

Document views: 10 File downloads:
  • van_fzs.pdf: 2