Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments

Rossier, Jeremie; Delasoie, Joachim; Haeni, Laetitia; Hauser, Daniel; Rothen-Rutishauser, Barbara; Zobi, Fabio

doi:10.1016/j.jinorgbio.2020.111122

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Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments

Rossier, Jeremie Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
Delasoie, Joachim Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
Haeni, Laetitia Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
Hauser, Daniel Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
Rothen-Rutishauser, Barbara Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
Zobi, Fabio Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland

26.05.2020

Published in:

Journal of Inorganic Biochemistry. - 2020, vol. 209, p. 111122

English A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2′-bipyridine and 5- ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules rapidly liberating on average ca. 2.3 equivalents of CO upon photo-irradiation. Complexes and conjugates were tested for their anticancer effects, both in the dark and following photo-activation, against breast cancer MCF-7, lung carcinoma A549 and colon adenocarcinoma HT29 cell lines as well as immortalized human bronchial epithelial cells 16HBE14o- as the non-carcinogenic control. Our results indicate that the light-induced cytotoxicity these molecules can be attributed to both their released CO and to their CO-depleted metal fragments including liberated ligands.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie, AMI - Bio-Nanomatériaux

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