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Cytotoxicity of Mn-based photoCORMs of ethynyl-α-diimine ligands against different cancer cell lines: The key role of CO-depleted metal fragments

  • Rossier, Jeremie Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
  • Delasoie, Joachim Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
  • Haeni, Laetitia Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
  • Hauser, Daniel Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
  • Rothen-Rutishauser, Barbara Adolphe Merkle Institute, Chemin des Verdiers 4, 1700 Fribourg, Switzerland
  • Zobi, Fabio Department of Chemistry, University of Fribourg, Chemin du Musée 9, 1700 Fribourg, Switzerland
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    26.05.2020
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  • Journal of Inorganic Biochemistry. - 2020, vol. 209, p. 111122
English A series of tricarbonyl manganese complexes bearing 4-ethynyl-2,2′-bipyridine and 5- ethynyl-1,10-phenanthroline α-diimine ligands were synthetized, characterized and conjugated to vitamin B12, previously used as a vector for drug delivery, to take advantage of its water solubility and specificity toward cancer cells. The compounds act as photoactivatable carbon monoxide-releasing molecules rapidly liberating on average ca. 2.3 equivalents of CO upon photo-irradiation. Complexes and conjugates were tested for their anticancer effects, both in the dark and following photo-activation, against breast cancer MCF-7, lung carcinoma A549 and colon adenocarcinoma HT29 cell lines as well as immortalized human bronchial epithelial cells 16HBE14o- as the non-carcinogenic control. Our results indicate that the light-induced cytotoxicity these molecules can be attributed to both their released CO and to their CO-depleted metal fragments including liberated ligands.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Biology
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https://folia.unifr.ch/unifr/documents/308744
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