Profiling parvalbumin interneurons using iPSC: challenges and perspectives for Autism Spectrum Disorder (ASD)
- Filice, Federica Department of Neuroscience and Movements Science, Section of Medicine, University of Fribourg, Switzerland
- Schwaller, Beat Department of Neuroscience and Movements Science, Section of Medicine, University of Fribourg, Switzerland
- Michel, Tanja M. Department of Psychiatry, Department of Clinical Research, University of Southern Denmark, Odense, Denmark - Psychiatry in the Region of Southern Denmark, Department of Psychiatry, Odense University Hospital Southern Denmark, Odense, Denmark - Research Unit for Psychiatry Odense, Institute for Clinical Research, University of Southern Denmark, Odense, Denmark
- Grünblatt, Edna Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry, University of Zurich, Switzerland - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland - Zurich Center for Integrative Human Physiology, University of Zurich, Switzerland
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29.01.2020
Published in:
- Molecular Autism. - 2020, vol. 11, no. 1, p. 10
English
Autism spectrum disorders (ASD) are persistent conditions resulting from disrupted/altered neurodevelopment. ASD multifactorial etiology—and its numerous comorbid conditions—heightens the difficulty in identifying its underlying causes, thus obstructing the development of effective therapies. Increasing evidence from both animal and human studies suggests an altered functioning of the parvalbumin (PV)- expressing inhibitory interneurons as a common and possibly unifying pathway for some forms of ASD. PV-expressing interneurons (short: PVALB neurons) are critically implicated in the regulation of cortical networks’ activity. Their particular connectivity patterns, i.e., their preferential targeting of perisomatic regions and axon initial segments of pyramidal cells, as well as their reciprocal connections, enable PVALB neurons to exert a fine-tuned control of, e.g., spike timing, resulting in the generation and modulation of rhythms in the gamma range, which are important for sensory perception and attention.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 328213
- DOI 10.1186/s13229-020-0314-0
- Persistent URL
- https://folia.unifr.ch/unifr/documents/308524
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