Journal article

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Neurons in the Nucleus papilio contribute to the control of eye movements during REM sleep

  • Gutierrez Herrera, C. Center for Experimental Neurology, Department of Neurology, Inselspital, University of Bern, Switzerland
  • Girard, Franck Anatomy and Program in Neuroscience, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Bilella, Alessandro Anatomy and Program in Neuroscience, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Gent, T. C. Center for Experimental Neurology, Department of Neurology, Inselspital, University of Bern, Switzerland
  • Roccaro-Waldmeyer, Diana M. Anatomy and Program in Neuroscience, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Adamantidis, A. Center for Experimental Neurology, Department of Neurology, Inselspital, University of Bern, Switzerland
  • Celio, Marco R. Anatomy and Program in Neuroscience, Faculty of Science and Medicine, University of Fribourg, Switzerland
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    19.11.2019
Published in:
  • Nature Communications. - 2019, vol. 10, no. 1, p. 1–11
English Rapid eye movements (REM) are characteristic of the eponymous phase of sleep, yet the underlying motor commands remain an enigma. Here, we identified a cluster of Calbindin-D28K-expressing neurons in the Nucleus papilio (NPCalb), located in the dorsal paragigantocellular nucleus, which are active during REM sleep and project to the three contralateral eye-muscle nuclei. The firing of opto-tagged NPCalb neurons is augmented prior to the onset of eye movements during REM sleep. Optogenetic activation of NPCalb neurons triggers eye movements selectively during REM sleep, while their genetic ablation or optogenetic silencing suppresses them. None of these perturbations led to a change in the duration of REM sleep episodes. Our study provides the first evidence for a brainstem premotor command contributing to the control of eye movements selectively during REM sleep in the mammalian brain.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308380
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