Medicine in the fourth dimension

Cederroth, Christopher R.; Albrecht, Urs; Bass, Joseph; Brown, Steven A.; Dyhrfjeld-Johnsen, Jonas; Gachon, Frederic; Green, Carla B.; Hastings, Michael H.; Helfrich-Förster, Charlotte; Hogenesch, John B.; Lévi, Francis; Loudon, Andrew; Lundkvist, Gabriella B.; Meijer, Johanna H.; Rosbash, Michael; Takahashi, Joseph S.; Young, Michael; Canlon, Barbara

doi:10.1016/j.cmet.2019.06.019

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Journal article

Medicine in the fourth dimension

Cederroth, Christopher R. Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden
Albrecht, Urs Department of Biology, Unit of Biochemistry, University of Fribourg, Fribourg, Switzerland
Bass, Joseph Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Brown, Steven A. Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
Dyhrfjeld-Johnsen, Jonas SENSORION SA, Montpellier, France
Gachon, Frederic Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia
Green, Carla B. Department of Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Hastings, Michael H. Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK
Helfrich-Förster, Charlotte Neurobiology and Genetics, Biocenter, Theodor-Boveri Institute, University of Würzburg, Würzburg, Germany
Hogenesch, John B. Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA
Lévi, Francis Cancer Chronotherapy Team, School of Medicine, University of Warwick, Coventry, UK - Warwick University on “Personalized Cancer Chronotherapeutics through System Medicine” (C2SysMed), European Associated Laboratory of the Unité Mixte de Recherche Scientifique 935, Institut National de la Santé et de la Recherche Médicale and Paris-Sud University, Villejuif, France - Department of Medical Oncology, Paul Brousse Hospital, Assistance Publique-Hopitaux de Paris, 94800 Villejuif, France
Loudon, Andrew School of Medicine, Faculty of Biology, Medicine and Health, University of Manchester, UK
Lundkvist, Gabriella B. Max Planck Institute for Biology of Ageing, Cologne, Germany
Meijer, Johanna H. Department of Neurophysiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands
Rosbash, Michael Department of Biology, Howard Hughes Medical Institute and National Center for Behavioral Genomics, Brandeis University, Waltham, MA 02453, USA
Takahashi, Joseph S. Howard Hughes Medical Institute, Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX, USA
Young, Michael Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA
Canlon, Barbara Experimental Audiology, Department of Physiology and Pharmacology, Karolinska Institutet, 171 77 Stockholm, Sweden

06.08.2019

Published in:

Cell Metabolism. - 2019, vol. 30, no. 2, p. 238–250

English The importance of circadian biology has rarely been considered in pre-clinical studies, and even more when translating to the bedside. Circadian biology is becoming a critical factor for improving drug efficacy and diminishing drug toxicity. Indeed, there is emerging evidence showing that some drugs are more effective at nighttime than daytime, whereas for others it is the opposite. This suggests that the biology of the target cell will determine how an organ will respond to a drug at a specific time of the day, thus modulating pharmacodynamics. Thus, it is now time that circadian factors become an integral part of translational research.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

Language