Journal article

Sex and age dependencies of aqueductal cerebrospinal fluid dynamics parameters in healthy subjects

  • Sartoretti, Thomas Laboratory of Translational Nutrition Biology, Department of Health Sciences and Technology, ETH Zürich, Switzerland
  • Wyss, Michael Philips Healthcare, Zurich, Switzerland - Department of Radiology, Cantonal Hospital Winterthur, Switzerland
  • Sartoretti, Elisabeth Department of Radiology, Cantonal Hospital Winterthur, Switzerland
  • Reischauer, Carolin Department of Radiology, Cantonal Hospital Winterthur, Switzerland - Department of Medicine, University of Fribourg, Switzerland - Department of Radiology, HFR Fribourg – Hôpital Cantonal, Fribourg, Switzerland
  • Hainc, Nicolin Department of Neuroradiology, University Hospital Zürich, University of Zürich, Switzerland
  • Graf, Nicole Graf Biostatistics, Winterthur, Switzerland
  • Binkert, Christoph Department of Radiology, Cantonal Hospital Winterthur, Switzerland
  • Najafi, Arash Department of Radiology, Cantonal Hospital Winterthur, Switzerland
  • Sartoretti-Schefer, Sabine Department of Radiology, Cantonal Hospital Winterthur, Switzerland
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    02.08.2019
Published in:
  • Frontiers in Aging Neuroscience. - 2019, vol. 11, p. 199
English Objectives: To assess the influence of age and sex on 10 cerebrospinal fluid (CSF) flow dynamics parameters measured with an MR phase contrast (PC) sequence within the cerebral aqueduct at the level of the intercollicular sulcus.Materials and Methods: 128 healthy subjects (66 female subjects with a mean age of 52.9 years and 62 male subjects with a mean age of 51.8 years) with a normal Evans index, normal medial temporal atrophy (MTA) score, and without known disorders of the CSF circulation were included in the study. A PC MR sequence on a 3T MR scanner was used. Ten different flow parameters were analyzed using postprocessing software. Ordinal and linear regression models were calculated.Results: The parameters stroke volume (sex: p < 0.001, age: p = 0.003), forward flow volume (sex: p < 0.001, age: p = 0.002), backward flow volume (sex: p < 0.001, age: p = 0.018), absolute stroke volume (sex: p < 0.001, age: p = 0.005), mean flux (sex: p < 0.001, age: p = 0.001), peak velocity (sex: p = 0.009, age: p = 0.0016), and peak pressure gradient (sex: p = 0.029, age: p = 0.028) are significantly influenced by sex and age. The parameters regurgitant fraction, stroke distance, and mean velocity are not significantly influenced by sex and age.Conclusion: CSF flow dynamics parameters measured in the cerebral aqueduct are partly age and sex dependent. For establishment of reliable reference values for clinical use in future studies, the impact of sex and age should be considered and incorporated.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308143
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