Journal article

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Multifunctional nano‐biointerfaces: cytocompatible antimicrobial nanocarriers from stabilizer‐free cubosomes

  • Zabara, Mahsa Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Senturk, Berna Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Gontsarik, Mark Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Ren, Qun Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Rottmar, Markus Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Maniura-Weber, Katharina Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland
  • Mezzenga, Raffaele Laboratory for Food and Soft Materials Science, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland
  • Bolisetty, Sreenath Laboratory for Food and Soft Materials Science, Institute of Food, Nutrition and Health, ETH Zurich, Switzerland
  • Salentinig, Stefan Laboratory for Biointerfaces, Department Materials meet Life, Empa Swiss Federal Laboratories for Materials Science and Technology, St. Gallen, Switzerland - Department of Chemistry, University of Fribourg, Switzerland
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    08.07.2019
Published in:
  • Advanced Functional Materials. - 2019, p. 1904007
English The rational design of alternative antimicrobial materials with reduced toxicity toward mammalian cells is highly desired due to the growing occurrence of bacteria resistant to conventional antibiotics. A promising approach is the design of lipid‐based antimicrobial nanocarriers. However, most of the commonly used polymer‐stabilized nanocarriers are cytotoxic. Herein, the design of a novel, stabilizer‐free nanocarrier for the human cathelicidin derived antimicrobial peptide LL‐37 that is cytocompatible and promotes cell proliferation for improved wound healing is reported. The nanocarrier is formed through the spontaneous integration of LL‐37 into novel, stabilizer‐free glycerol mono‐oleate (GMO)‐based cubosomes. Transformations in the internal structure of the cubosomes from Pn3m to Im3m‐type and eventually their transition into small vesicles and spherical micelles are demonstrated upon the encapsulation of LL‐37 into their internal bicontinuous cubic structure using small angle X‐ray scattering, cryogenic transmission electron microscopy, and light scattering techniques. Additional in vitro biological assays show the antimicrobial activity of the stabilizer‐free nano‐objects on a variety of bacteria strains, their cytocompatibility, and cell‐ proliferation enhancing effect. The results outline a promising strategy for the comprehensive design of antimicrobial, cytocompatible lipid nanocarriers for the protection and delivery of bioactive molecules with potential for application as advanced wound healing materials.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308116
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