Phase transformation of superparamagnetic iron oxide nanoparticles via thermal annealing: implications for hyperthermia applications

Crippa, Federica; Rodriguez-Lorenzo, Laura; Hua, Xiao; Goris, Bart; Bals, Sara; Garitaonandia, José S.; Balog, Sandor; Burnand, David; Hirt, Ann M.; Haeni, Laetitia; Lattuada, Marco; Rothen-Rutishauser, Barbara; Petri-Fink, Alke

doi:10.1021/acsanm.9b00823

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Phase transformation of superparamagnetic iron oxide nanoparticles via thermal annealing: implications for hyperthermia applications

Crippa, Federica Adolphe Merkle Institute, University of Fribourg, Switzerland
Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, University of Fribourg, Switzerland - Water4Environment Unit, International Iberian Nanotechnology Laboratory, Braga, Portugal
Hua, Xiao Adolphe Merkle Institute, University of Fribourg, Switzerland
Goris, Bart Electron Microscopy for Materials Research, University of Antwerp, Belgium
Bals, Sara Electron Microscopy for Materials Research, University of Antwerp, Belgium
Garitaonandia, José S. Zientzia eta Teknologia Fakultatea. Euskal Herriko Unibertsitatea, Bilbao, Spain
Balog, Sandor Adolphe Merkle Institute, University of Fribourg, Switzerland
Burnand, David Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
Hirt, Ann M. Institute for Geophysics, ETH Zurich, Switzerland
Haeni, Laetitia Adolphe Merkle Institute, University of Fribourg, Switzerland
Lattuada, Marco Chemistry Department, University of Fribourg, Switzerland
Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland
Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland

26.07.2019

Published in:

ACS Applied Nano Materials. - 2019, vol. 2, no. 7, p. 4462–4470

English Magnetic hyperthermia has the potential to play an important role in cancer therapy and its efficacy relies on the nanomaterials selected. Superparamagnetic iron oxide nanoparticles (SPIONs) are excellent candidates due to the ability of producing enough heat to kill tumor cells by thermal ablation. However, their heating properties depend strongly on crystalline structure and size, which may not be controlled and tuned during the synthetic process; therefore, a postprocessing is needed. We show how thermal annealing can be simultaneously coupled with ligand exchange to stabilize the SPIONs in polar solvents and to modify their crystal structure, which improves hyperthermia behavior. Using high-resolution transmission electron microscopy, X-ray diffraction, Mössbauer spectroscopy, vibrating sample magnetometry, and lock-in thermography, we systematically investigate the impact of size and ligand exchange procedure on crystallinity, their magnetism, and heating ability. We describe a valid and simple approach to optimize SPIONs for hyperthermia by carefully controlling the size, colloidal stability, and crystallinity.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie, AMI - Bio-Nanomatériaux

Language