Journal article
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Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy
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Jakubaszek, Marta
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France - Institut Curie, PSL University, CNRS UMR 144, Paris, France
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Rossier, Jeremie
Chemistry Department, University of Fribourg, Switzerland
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Karges, Johannes
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
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Delasoie, Joachim
Chemistry Department, University of Fribourg, Switzerland
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Goud, Bruno
Institut Curie, PSL University, CNRS UMR 144, Paris, France
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Gasser, Gilles
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
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Zobi, Fabio
Chemistry Department, University of Fribourg, Switzerland
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Published in:
- Helvetica Chimica Acta. - 2019, vol. 102, no. 7, p. e1900104
English
The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Chemistry
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/308091
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