Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy

Jakubaszek, Marta; Rossier, Jeremie; Karges, Johannes; Delasoie, Joachim; Goud, Bruno; Gasser, Gilles; Zobi, Fabio

doi:10.1002/hlca.201900104

Back

Journal article

+ 1 other files

Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy

Jakubaszek, Marta Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France - Institut Curie, PSL University, CNRS UMR 144, Paris, France
Rossier, Jeremie Chemistry Department, University of Fribourg, Switzerland
Karges, Johannes Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
Delasoie, Joachim Chemistry Department, University of Fribourg, Switzerland
Goud, Bruno Institut Curie, PSL University, CNRS UMR 144, Paris, France
Gasser, Gilles Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
Zobi, Fabio Chemistry Department, University of Fribourg, Switzerland

2019

Published in:

Helvetica Chimica Acta. - 2019, vol. 102, no. 7, p. e1900104

English The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language