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Evaluation of the potential of cobalamin derivatives bearing ru(ii) polypyridyl complexes as photosensitizers for photodynamic therapy

  • Jakubaszek, Marta Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France - Institut Curie, PSL University, CNRS UMR 144, Paris, France
  • Rossier, Jeremie Chemistry Department, University of Fribourg, Switzerland
  • Karges, Johannes Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
  • Delasoie, Joachim Chemistry Department, University of Fribourg, Switzerland
  • Goud, Bruno Institut Curie, PSL University, CNRS UMR 144, Paris, France
  • Gasser, Gilles Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, France
  • Zobi, Fabio Chemistry Department, University of Fribourg, Switzerland
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    2019
Published in:
  • Helvetica Chimica Acta. - 2019, vol. 102, no. 7
English The current photosensitizers (PSs) for photodynamic therapy (PDT) lack selectivity for cancer cells. To tackle this drawback, in view of selective cancer delivery, we envisioned conjugating two ruthenium polypyridyl complexes to vitamin B12 (Cobalamin, Cbl) to take advantage of the solubility and active uptake of the latter. Ultimately, our results showed that the transcobalamin pathway is unlikely involved for the delivery of these ruthenium‐based PDT PSs, emphasizing the difficulty in successfully delivering metal complexes to cancer cells.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308091
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