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Muscarinic acetylcholine receptor signaling generates OFF selectivity in a simple visual circuit

  • Qin, Bo National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA
  • Humberg, Tim-Henning Department of Biology, University of Fribourg, Switzerland -
  • Kim, Anna National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA -
  • Kim, Hyong S. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA
  • Short, Jacob National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA
  • Diao, Fengqiu National Institute of Mental Health, National Institutes of Health, Bethesda, USA
  • White, Benjamin H. National Institute of Mental Health, National Institutes of Health, Bethesda, USA
  • Sprecher, Simon G. Department of Biology, University of Fribourg, Switzerland
  • Yuan, Quan National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA
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    09.09.2019
Published in:
  • Nature Communications. - 2019, vol. 10, no. 1, p. 1–16
English ON and OFF selectivity in visual processing is encoded by parallel pathways that respond to either light increments or decrements. Despite lacking the anatomical features to support split channels, Drosophila larvae effectively perform visually- guided behaviors. To understand principles guiding visual computation in this simple circuit, we focus on investigating the physiological properties and behavioral relevance of larval visual interneurons. We find that the ON vs. OFF discrimination in the larval visual circuit emerges through light-elicited cholinergic signaling that depolarizes a cholinergic interneuron (cha-lOLP) and hyperpolarizes a glutamatergic interneuron (glu-lOLP). Genetic studies further indicate that muscarinic acetylcholine receptor (mAchR)/Gαo signaling produces the sign-inversion required for OFF detection in glu-lOLP, the disruption of which strongly impacts both physiological responses of downstream projection neurons and dark-induced pausing behavior. Together, our studies identify the molecular and circuit mechanisms underlying ON vs. OFF discrimination in the Drosophila larval visual system.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/308087
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