Initiated by CREB: resolving gene regulatory programs in learning and memory: switch in cofactors and transcription regulators between memory consolidation and maintenance network

Kaldun, Jenifer C.; Sprecher, Simon G.

doi:10.1002/bies.201900045

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Journal article

Initiated by CREB: resolving gene regulatory programs in learning and memory: switch in cofactors and transcription regulators between memory consolidation and maintenance network

Kaldun, Jenifer C. Department of Biology, University of Fribourg, Switzerland
Sprecher, Simon G. Department of Biology, University of Fribourg, Switzerland

2019

Published in:

BioEssays. - 2019, vol. 41, no. 8, p. 1900045

English Consolidation of long‐term memory is a highly and precisely regulated multistep process. The transcription regulator cAMP response element‐binding protein (CREB) plays a key role in initiating memory consolidation. With time processing, first the cofactors are changed and, secondly, CREB gets dispensable. This ultimately changes the expressed gene program to genes required to maintain the memory. Regulation of memory consolidation also requires epigenetic mechanisms and control at the RNA level. At the neuronal circuit level, oscillation in the activity of CREB and downstream factor define engram cells. Together the combination of all regulation mechanisms allows correct memory processing while keeping the process dynamic and flexible to adjust to different contexts.

Faculty

Faculté des sciences et de médecine

Department

Département de Biologie

Language