Journal article

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Altering the temporal regulation of one transcription factor drives evolutionary trade-offs between head sensory organs

  • Ramaekers, Ariane Institut du Cerveau et de la Moelle Epinière (ICM) - Hôpital Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, France -
  • Claeys, Annelies VIB Center for Brain and Disease, VIB, Leuven, Belgium - Center for Human Genetics, University of Leuven School of Medicine, Leuven, Belgium
  • Kapun, Martin Department of Biology, University of Fribourg, Switzerland -
  • Mouchel-Vielh, Emmanuèle Sorbonne Université, CNRS, Laboratoire de Biologie du Développement, Institut de Biologie Paris Seine, LBD-IBPS), Paris, France
  • Potier, Delphine Aix-Marseille Université, CNRS, INSERM, CIML, Marseille, France
  • Weinberger, Simon VIB Center for Brain and Disease, VIB, Leuven, Belgium - Center for Human Genetics, University of Leuven School of Medicine, Leuven, Belgium
  • Grillenzoni, Nicola Institut du Cerveau et de la Moelle Epinière (ICM) - Hôpital Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, France
  • Dardalhon-Cuménal, Delphine Sorbonne Université, CNRS, Laboratoire de Biologie du Développement, Institut de Biologie Paris Seine, LBD-IBPS), Paris, France
  • Yan, Jiekun VIB Center for Brain and Disease, VIB, Leuven, Belgium - Center for Human Genetics, University of Leuven School of Medicine, Leuven, Belgium
  • Wolf, Reinhard Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg, Germany
  • Flatt, Thomas Department of Biology, University of Fribourg, Switzerland
  • Buchner, Erich Institute for Clinical Neurobiology, University Hospital Würzburg, Germany
  • Hassan, Bassem A. Institut du Cerveau et de la Moelle Epinière (ICM) - Hôpital Pitié-Salpêtrière, Sorbonne Université, Inserm, CNRS, Paris, France -
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    23.09.2019
Published in:
  • Developmental Cell. - 2019, vol. 50, no. 6, p. 780-792.e7
English Size trade-offs of visual versus olfactory organs is a pervasive feature of animal evolution. This could result from genetic or functional constraints. We demonstrate that head sensory organ size trade-offs in Drosophila are genetically encoded and arise through differential subdivision of the head primordium into visual versus non- visual fields. We discover that changes in the temporal regulation of the highly conserved eyeless/Pax6 gene expression during development is a conserved mechanism for sensory trade-offs within and between Drosophila species. We identify a natural single nucleotide polymorphism in the cis-regulatory region of eyeless in a binding site of its repressor Cut that is sufficient to alter its temporal regulation and eye size. Because eyeless/Pax6 is a conserved regulator of head sensory placode subdivision, we propose that its temporal regulation is key to define the relative size of head sensory organs.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307950
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