Characterization of PAN-1, a carbapenem-hydrolyzing class b β-lactamase from the environmental gram-negative Pseudobacteriovorax antillogorgiicola
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Kieffer, Nicolas
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Department of Medicine, INSERM European Unit (IAME, France), University of Fribourg, Switzerland
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Poirel, Laurent
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Department of Medicine, INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Department of Medicine, Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland
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Fournier, Claudine
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Department of Medicine, INSERM European Unit (IAME, France), University of Fribourg, Switzerland
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Haltli, Brad
Department of Biomedical Sciences, Atlantic Veterinary College, Charlottetown, Canada
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Kerr, Russel
Department of Biomedical Sciences, Atlantic Veterinary College, Charlottetown, Canada
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Nordmann, Patrice
Medical and Molecular Microbiology Unit, Department of Medicine, Faculty of Science, University of Fribourg, Switzerland - Department of Medicine, INSERM European Unit (IAME, France), University of Fribourg, Switzerland - Department of Medicine, Swiss National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg, Switzerland - Department of Medicine, Institute for Microbiology, University of Lausanne and University Hospital Centre, Lausanne, Switzerland
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Published in:
- Frontiers in Microbiology. - 2019, vol. 10, p. 1673
English
The gene encoding the metallo-β-lactamase (MβL) PAN-1 was identified in the genome of the environmental Gram-negative species Pseudobacteriovorax antillogorgiicola. PAN-1 shares 57% amino-acid identity with the acquired MβL SPM- 1, its closest relative. Kinetic parameters performed on purified PAN-1 showed it displayed a hydrolytic activity toward most β-lactams including carbapenems but spared cefepime and aztreonam. These results further highlight that environmental bacterial species may be reservoirs of MβL encoding genes.
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine 3ème année
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307933
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