Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert; Ngono Bikobo, Dominique Serge; Zintchem, Auguste Abouem A.; Mbabi Nyemeck II, Norbert; Moni Ndedi, Esther Del Florence; Betote Diboué, Patrick Hervé; Nyegue, Maximilienne Ascension; Atchadé, Alex de Théodore; Pegnyemb, Dieudonné Emmanuel; Bochet, Christian G.; Koert, Ulrich

doi:10.1080/14786419.2017.1402324

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Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis

Tiam, Eric Robert Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
Ngono Bikobo, Dominique Serge Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Department Chemie, Universität Fribourg, Fribourg, Switzerland
Zintchem, Auguste Abouem A. Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Department of Chemistry, Higher Training College, University of Yaoundé I, Yaoundé, Cameroon
Mbabi Nyemeck II, Norbert Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
Moni Ndedi, Esther Del Florence Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
Betote Diboué, Patrick Hervé Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
Nyegue, Maximilienne Ascension Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
Atchadé, Alex de Théodore Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
Pegnyemb, Dieudonné Emmanuel Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
Bochet, Christian G. Department Chemie, Universität Fribourg, Fribourg, Switzerland
Koert, Ulrich Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany

04.03.2019

Published in:

Natural Product Research. - 2019, vol. 33, no. 5, p. 642–650

English Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D- glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language