Journal article
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Secondary metabolites from Triclisia gilletii (De Wild) Staner (Menispermaceae) with antimycobacterial activity against Mycobacterium tuberculosis
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Tiam, Eric Robert
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
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Ngono Bikobo, Dominique Serge
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Department Chemie, Universität Fribourg, Fribourg, Switzerland
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Zintchem, Auguste Abouem A.
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Department of Chemistry, Higher Training College, University of Yaoundé I, Yaoundé, Cameroon
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Mbabi Nyemeck II, Norbert
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon - Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
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Moni Ndedi, Esther Del Florence
Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
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Betote Diboué, Patrick Hervé
Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
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Nyegue, Maximilienne Ascension
Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
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Atchadé, Alex de Théodore
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
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Pegnyemb, Dieudonné Emmanuel
Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
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Bochet, Christian G.
Department Chemie, Universität Fribourg, Fribourg, Switzerland
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Koert, Ulrich
Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
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Published in:
- Natural Product Research. - 2019, vol. 33, no. 5, p. 642–650
English
Triclisinone (2), a new ochnaflavone derivative, was isolated from the aerial parts of Triclisia gilletii, along with known drypemolundein B (1) and eight other known compounds. The chemical shifts of drypemolundein B (1) have been partially revised based on reinterpretation of NMR spectroscopic data. The eight other secondary metabolites are composed of: (+)-nonacosan-10-ol (3); stigmasterol (4), 3-O-β-D- glucopyranosylsitosterol (5), 3-O-β-D-glucopyranosylstigmasterol (6); oleanic acid (7); myricetin (8), quercetin (9) and 3-methoxyquercetin (10). Their structures were elucidated using IR, MS, NMR 1D and 2D, 1H and 13C and comparison with literature data. Furthermore, compounds 1, 2, 5, 6, 8, 9 and the crude extract were tested against Mycobacterium tuberculosis. Compounds 1, 2, 8 and 9 displayed moderate to very good activity against resistant strain (codified AC 45) of M. tuberculosis with minimum inhibitory concentrations MICs ranging from 3.90 to 62.5 μg/mL.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307909
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