Journal article
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Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity
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Rus, Florentina
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Flatt, Thomas
Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, USA - Department of Ecology and Evolution, University of Lausanne, Switzerland
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Tong, Mei
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Aggarwal, Kamna
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Okuda, Kendi
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Kleino, Anni
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Yates, Elisabeth
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Tatar, Marc
Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, USA
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Silverman, Neal
Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
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Published in:
- The EMBO Journal. - 2013, vol. 32, no. 11, p. 1626–1638
English
Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. We identify a group of steroid‐regulated transcription factors as well as two GATA transcription factors that act as repressors and activators of the immune response and are required for the proper hormonal control of PGRP‐LC expression. Together, our results demonstrate that Drosophila use complex mechanisms to modulate innate immune responses, and identify a transcriptional hierarchy that integrates steroid signalling and immunity in animals.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Biologie
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307682
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