Ecdysone triggered PGRP‐LC expression controls Drosophila innate immunity
- Rus, Florentina Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Flatt, Thomas Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, USA - Department of Ecology and Evolution, University of Lausanne, Switzerland
- Tong, Mei Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Aggarwal, Kamna Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Okuda, Kendi Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Kleino, Anni Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Yates, Elisabeth Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
- Tatar, Marc Department of Ecology and Evolutionary Biology, Division of Biology and Medicine, Brown University, Providence, USA
- Silverman, Neal Department of Medicine, Division of Infectious Disease, University of Massachusetts Medical School, Worcester, USA
-
29.05.2013
Published in:
- The EMBO Journal. - 2013, vol. 32, no. 11, p. 1626–1638
English
Throughout the animal kingdom, steroid hormones have been implicated in the defense against microbial infection, but how these systemic signals control immunity is unclear. Here, we show that the steroid hormone ecdysone controls the expression of the pattern recognition receptor PGRP‐LC in Drosophila, thereby tightly regulating innate immune recognition and defense against bacterial infection. We identify a group of steroid‐regulated transcription factors as well as two GATA transcription factors that act as repressors and activators of the immune response and are required for the proper hormonal control of PGRP‐LC expression. Together, our results demonstrate that Drosophila use complex mechanisms to modulate innate immune responses, and identify a transcriptional hierarchy that integrates steroid signalling and immunity in animals.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
-
- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
-
- RERO DOC 324283
- DOI 10.1038/emboj.2013.100
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307682
Other files
Statistics
Document views: 37
File downloads:
- 2013_etp.pdf: 108
- 2013_etp_sm.pdf: 71