Toolbox for in vivo imaging of host–parasite interactions at multiple scales

Niz, Mariana De; Spadin, Florentin; Marti, Matthias; Stein, Jens V.; Frenz, Martin; Frischknecht, Friedrich

doi:10.1016/j.pt.2019.01.002

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Journal article

Toolbox for in vivo imaging of host–parasite interactions at multiple scales

Niz, Mariana De Institute of Cell Biology – Heussler Laboratory, University of Bern, Switzerland - Wellcome Centre for Molecular Parasitology, University of Glasgow, UK - Instituto de Medicina Molecular – João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal
Spadin, Florentin Institute of Applied Physics, University of Bern, Switzerland
Marti, Matthias Wellcome Centre for Molecular Parasitology, University of Glasgow, UK
Stein, Jens V. Theodor Kocher Institute, University of Bern, Switzerland - Department of Oncology, Microbiology and Immunology, University of Fribourg, Switzerland
Frenz, Martin Institute of Applied Physics, University of Bern, Switzerland
Frischknecht, Friedrich Integrative Parasitology, Centre for Infectious Diseases, Heidelberg University Medical School, Heidelberg, Germany

01.03.2019

Published in:

Trends in Parasitology. - 2019, vol. 35, no. 3, p. 193–212

English Animal models have for long been pivotal for parasitology research. Over the last few years, techniques such as intravital, optoacoustic and magnetic resonance imaging, optical projection tomography, and selective plane illumination microscopy developed promising potential for gaining insights into host–pathogen interactions by allowing different visualization forms in vivo and ex vivo. Advances including increased resolution, penetration depth, and acquisition speed, together with more complex image analysis methods, facilitate tackling biological problems previously impossible to study and/or quantify. Here we discuss advances and challenges in the in vivo imaging toolbox, which hold promising potential for the field of parasitology.

Faculty

Faculté des sciences et de médecine

Department

Département de Médecine

Language