Magneto-responsive cell culture substrates that can be modulated in situ

Crippa, Federica; Rothen-Rutishauser, Barbara; Petri-Fink, Alke

doi:10.2533/chimia.2019.51

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Journal article

Magneto-responsive cell culture substrates that can be modulated in situ

Crippa, Federica Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
Rothen-Rutishauser, Barbara Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
Petri-Fink, Alke Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland

27.02.2019

Published in:

CHIMIA International Journal for Chemistry. - 2019, vol. 73, no. 1, p. 51–54

English Understanding the interaction between cells and their environment is fundamental for mechanobiology. To mimic the behavior of cells in physiological and pathological conditions, synthetic substrates must have topographical and/or mechanical properties that evolve in time. Dynamic substrates mainly rely on stimuli-responsive materials where an external stimulus induces controlled variations in topography or mechanics. Herein, we describe the development of a dynamic cell culture substrate where mechanical properties are reversibly tuned in situ using magnetically- responsive superparamagnetic iron oxide nanoparticles (SPIONs).

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie, AMI - Bio-Nanomatériaux

Language