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Journal article

Structural brain differences predict early traumatic memory processing

  • Gvozdanovic, Geraldine Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich Switzerland
  • Stämpfli, Philipp Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich Switzerland, MR-Center of the Department of Psychiatry, Psychotherapy and Psychosomatics and the Department of Child and Adolescent Psychiatry, Psychiatric Hospital of the University of Zürich, Zürich, Switzerland.
  • Seifritz, Erich Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zürich, Zürich Switzerland, Competence Center of Sleep & Health Zurich, University of Zürich, Switzerland
  • Rasch, Björn Department of Psychology, University of Fribourg, Fribourg, Switzerland, Competence Center of Sleep & Health Zurich, University of Zürich, Switzerland
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    02.03.2019
Published in:
  • Psychophysiology. - 2019, no. Special Issue: "The psychophysiology of trauma exposure", p. 1-11
Structural MRI
voxel-based morphometry (VBM)
trauma film paradigm
early intrusive memories
PTSD
English Intrusive memories are a key symptom of post-traumatic stress disorder (PTSD). They emerge early after trauma exposure and are predictive for PTSD development. There is a high relevance in evaluating the neurobiological mechanisms of early stages of intrusive symptom development to provide a further understanding of PTSD. In the present study, we explore structural differences in healthy young female subjects preceding experimental trauma exposure and their relationship to early intrusive memory development using a traumatic film paradigm. With voxel-based morphometry, we demonstrate that smaller insular volume was associated with an increased number of early intrusive film memories. Moreover, larger lingual gyrus/cerebellar and inferior frontal gyrus/precentral gyrus volumes were also related to an increased number of early intrusive film memories. Our results identify unique brain areas associated with early experimental trauma memory processing and highlight the necessity of evaluating early symptom stages relevant for personalized PTSD prevention and treatment.
Faculty
Faculté des lettres et des sciences humaines
Department
Département de Psychologie
Language
  • English
Classification
Psychology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307634
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