Journal article

Artificial lysosomal platform to study nanoparticle long-term stability

  • Milosevic, Ana Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen
  • Bourquin, Joël Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Burnand, David Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Federal Department of Economic Affairs, Education, and Research, EAER, Laboratory of ‘Proteins + Metabolites’, Agroscope, Bern, Switzerland
  • Lemal, Philipp Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Crippa, Federica Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
  • Monnier, Christophe A. Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Waite Research Lab, Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, USA
  • Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - INL – International Iberian Nanotechnology Laboratory, Braga, Portugal
  • Petri-Fink, Alke Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Department of Chemistry, University of Fribourg, Switzerland
  • Rothen-Rutishauser, Barbara Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
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    27.02.2019
Published in:
  • CHIMIA International Journal for Chemistry. - 2019, vol. 73, no. 1, p. 55–58
English Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex environment of lysosomes, a compartment which can be mimicked by artificial lysosomal fluid. In this work we showed the applicability of lysosomal fluid as a platform for a fast assessment of gold, iron oxide and silica NP stability over 24 h in a relevant biological fluid, by using multiple analytical methods.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307621
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