Artificial lysosomal platform to study nanoparticle long-term stability
- Milosevic, Ana Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Swiss Federal Laboratories for Materials Science and Technology (Empa), St. Gallen
- Bourquin, Joël Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
- Burnand, David Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Federal Department of Economic Affairs, Education, and Research, EAER, Laboratory of ‘Proteins + Metabolites’, Agroscope, Bern, Switzerland
- Lemal, Philipp Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
- Crippa, Federica Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
- Monnier, Christophe A. Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Waite Research Lab, Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, USA
- Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - INL – International Iberian Nanotechnology Laboratory, Braga, Portugal
- Petri-Fink, Alke Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland - Department of Chemistry, University of Fribourg, Switzerland
- Rothen-Rutishauser, Barbara Adolphe Merkle Institute, Faculty of Science and Medicine, University of Fribourg, Switzerland
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27.02.2019
Published in:
- CHIMIA International Journal for Chemistry. - 2019, vol. 73, no. 1, p. 55–58
English
Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedi- cal applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex environment of lysosomes, a compartment which can be mimicked by artificial lysosomal fluid. In this work we showed the applicability of lysosomal fluid as a platform for a fast assessment of gold, iron oxide and silica NP stability over 24 h in a relevant biological fluid, by using multiple analytical methods.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 324662
- DOI 10.2533/chimia.2019.55
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307621
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