Journal article

Neuronal inputs and outputs of aging and longevity

  • Alcedo, Joy Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland - Department of Biological Sciences, Wayne State University, Detroit, USA
  • Flatt, Thomas Institut für Populationsgenetik, Vetmeduni Vienna, Vienna, Austria - Wissenschaftskolleg zu Berlin, Institute for Advanced Study, Berlin, Germany - Department of Biology, University of Fribourg, Switzerland
  • Pasyukova, Elena G. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
Published in:
  • Frontiers in Genetics. - 2013, vol. 4, p. 71
English An animal’s survival strongly depends on its ability to maintain homeostasis in response to the changing quality of its external and internal environment. This is achieved through intracellular and intercellular communication within and among different tissues. One of the organ systems that plays a major role in this communication and the maintenance of homeostasis is the nervous system. Here we highlight different aspects of the neuronal inputs and outputs of pathways that affect aging and longevity. Accordingly, we discuss how sensory inputs influence homeostasis and lifespan through the modulation of different types of neuronal signals, which reflects the complexity of the environmental cues that affect physiology. We also describe feedback, compensatory and feed-forward mechanisms in these longevity-modulating pathways that are necessary for homeostasis. Finally, we consider the temporal requirements for these neuronal processes and the potential role of natural genetic variation in shaping the neurobiology of aging.
Faculté des sciences et de médecine
Département de Biologie
  • English
Biological sciences
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