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Somatosensory and auditory deviance detection for outcome prediction during postanoxic coma

  • Pfeiffer, Christian Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) and University of Lausanne, Switzerland
  • Nguissi, Nathalie Ata Nguepnjo Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) and University of Lausanne, Switzerland
  • Chytiris, Magali Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) and University of Lausanne, Switzerland
  • Bidlingmeyer, Phanie Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) and University of Lausanne, Switzerland
  • Haenggi, Matthias Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Switzerland
  • Kurmann, Rebekka Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
  • Zubler, Frédéric Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Switzerland
  • Accolla, Ettore A. Neurology Unit, Department of Medicine, Hôpital Cantonal Fribourg (HFR), Switzerland - Laboratory for Cognitive and Neurological Sciences, Department of Medicine, University of Fribourg, Switzerland
  • Viceic, Dragana Neurology Service, Hôpital du Valais, Sion, Switzerland
  • Rusca, Marco Intensive Care Medicine, Hôpital du Valais, Sion, Switzerland
  • Oddo, Mauro Department of Intensive Care Medicine, University Hospital (CHUV) and University of Lausanne, Switzerland
  • Rossetti, Andrea O. Neurology Service, University Hospital (CHUV) and University of Lausanne, Switzerland
  • Lucia, Marzia De Laboratoire de Recherche en Neuroimagerie (LREN), University Hospital (CHUV) and University of Lausanne, Switzerland
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    01.09.2018
Published in:
  • Annals of Clinical and Translational Neurology. - 2018, vol. 5, no. 9, p. 1016–1024
English Objective: Prominent research in patients with disorders of consciousness investigated the electrophysiological correlates of auditory deviance detection as a marker of consciousness recovery. Here, we extend previous studies by investigating whether somatosensory deviance detection provides an added value for outcome prediction in postanoxic comatose patients.Methods: Electroencephalography responses to frequent and rare stimuli were obtained from 66 patients on the first and second day after coma onset.Results: Multivariate decoding analysis revealed an above chance‐level auditory discrimination in 25 patients on the first day and in 31 patients on the second day. Tactile discrimination was significant in 16 patients on the first day and in 23 patients on the second day. Single‐day sensory discrimination was unrelated to patients’ outcome in both modalities. However, improvement of auditory discrimination from first to the second day was predictive of good outcome with a positive predictive power (PPV) of 0.73 (CI = 0.52–0.88). Analyses considering the improvement of tactile, auditory and tactile, or either auditory or tactile discrimination showed no significant prediction of good outcome (PPVs = 0.58–0.68).Interpretation: Our results show that in the acute phase of coma deviance detection is largely preserved for both auditory and tactile modalities. However, we found no evidence for an added value of somatosensory to auditory deviance detection function for coma‐ outcome prediction.
Faculty
Faculté des sciences et de médecine
Department
Médecine 3ème année
Language
  • English
Classification
Medicine
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307340
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