Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation

Chabert, Valentin; Hologne, Maggy; Sénèque, Olivier; Walker, Olivier; Fromm, Katharina M.

doi:10.1039/C8CC03784A

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Alpha-helical folding of SilE models upon Ag(His)(Met) motif formation

Chabert, Valentin University of Fribourg, Department of Chemistry, Switzerland
Hologne, Maggy Université de Lyon, CNRS, UCB Lyon 1, ENS-Lyon, Institut des Sciences Analytiques, UMR 5280, Villeurbanne, France
Sénèque, Olivier Université Grenoble Alpes, CNRS, CEA, BIG/LCBM (UMR 5249), Grenoble, France
Walker, Olivier Université de Lyon, CNRS, UCB Lyon 1, ENS-Lyon, Institut des Sciences Analytiques, UMR 5280, Villeurbanne, France
Fromm, Katharina M. University of Fribourg, Department of Chemistry, Switzerland

13.09.2018

Published in:

Chemical Communications. - 2018, vol. 54, no. 74, p. 10419–10422

English The SilE protein is suspected to have a prominent role in Ag+ detoxification of silver resistant bacteria. Using model peptides, we elucidated both qualitative and quantitative aspects of the Ag+-induced α-helical structuring role of His- and Met-rich sequences of SilE, improving our understanding of its function within the Sil system.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language