Journal article
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A rational and iterative process for targeted nanoparticle design and validation
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Rodriguez-Lorenzo, Laura
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Rafiee, Sarah D.
Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
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Reis, Corine
Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
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Milosevic, Ana
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Moore, Thomas L.
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Balog, Sandor
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Rothen-Rutishauser, Barbara
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Rüegg, Curzio
Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
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Petri-Fink, Alke
Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
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Published in:
- Colloids and Surfaces B: Biointerfaces. - 2018, vol. 171, p. 579–589
English
The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi- parametric approach to fully characterize targeted nanoparticles, and emphasizes the significant effect that each detail in the synthetic process can have on downstream in vitro results. Through an iterative process, particles were designed, synthesized and tested for physico-chemical and bio-interactive properties which allowed the optimization of nanoparticle functionality. Taken together all interative steps demonstrate that we have synthesized a multifunctional gold nanoparticles that can detect ERBB2-positive breast cancer cells while showing stealth-like behavior toward ERBB2-negative cells and excellent physicochemical stability.
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Faculty
- Faculté des sciences et de médecine
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Department
- AMI - Bio-Nanomatériaux, Médecine 3ème année
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307307
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