A rational and iterative process for targeted nanoparticle design and validation
- Rodriguez-Lorenzo, Laura Adolphe Merkle Institute, University of Fribourg, Switzerland
- Rafiee, Sarah D. Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
- Reis, Corine Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
- Milosevic, Ana Adolphe Merkle Institute, University of Fribourg, Switzerland
- Moore, Thomas L. Adolphe Merkle Institute, University of Fribourg, Switzerland
- Balog, Sandor Adolphe Merkle Institute, University of Fribourg, Switzerland
- Rothen-Rutishauser, Barbara Adolphe Merkle Institute, University of Fribourg, Switzerland
- Rüegg, Curzio Deparment of Oncology, Microbiology and Immunology, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
- Petri-Fink, Alke Adolphe Merkle Institute, University of Fribourg, Switzerland - Chemistry Department, Faculty of Sciences and Medicine, University of Fribourg, Switzerland
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01.11.2018
Published in:
- Colloids and Surfaces B: Biointerfaces. - 2018, vol. 171, p. 579–589
English
The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi- parametric approach to fully characterize targeted nanoparticles, and emphasizes the significant effect that each detail in the synthetic process can have on downstream in vitro results. Through an iterative process, particles were designed, synthesized and tested for physico-chemical and bio-interactive properties which allowed the optimization of nanoparticle functionality. Taken together all interative steps demonstrate that we have synthesized a multifunctional gold nanoparticles that can detect ERBB2-positive breast cancer cells while showing stealth-like behavior toward ERBB2-negative cells and excellent physicochemical stability.
- Faculty
- Faculté des sciences et de médecine
- Department
- AMI - Bio-Nanomatériaux, Médecine 3ème année
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 323331
- DOI 10.1016/j.colsurfb.2018.07.066
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307307
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