Journal article

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

  • Lannes, Nils Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Eppler, Elisabeth Pestalozzistrasse Zo, Department of BioMedicine, University of Basel, Switzerland
  • Etemad, Samar Centre for Clinical Research, The University of Queensland, Brisbane, Australia
  • Yotovski, Peter Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Filgueira, Luis Anatomy, Department of Medicine, University of Fribourg, Switzerland
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    11.12.2017
Published in:
  • Oncotarget. - 2017, vol. 8, no. 69, p. 114393–114413
English Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a major contribution to adult neurogenesis and neuroinflammation. Thus, they participate in the pathogenesis of neurodegenerative diseases and contribute to aging. They play an important role in sustaining and breaking the blood-brain barrier. As innate immune cells, they contribute substantially to the immune response against infectious agents affecting the CNS. They play also a major role in the growth of tumours of the CNS. Microglia are consequently the key cell population linking the nervous and the immune system. This review covers all different aspects of microglia biology and pathology in a comprehensive way.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307303
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