Rauvolfianine, a new antimycobacterial glyceroglycolipid and other constituents from Rauvolfia caffra. Sond (Apocynaceae)
- Messanga, Robert Ebeh Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Ngono Bikobo, Dominique Serge Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Zintchem, Auguste Abouem A. Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Mbabi Nyemeck II, Norbert Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Moni Ndedi, Esther Del Florence Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
- Betote Diboué, Patrick Hervé Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
- Nyegue, Maximilienne Ascension Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon
- Atchadé, Alex de Théodore Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Pegnyemb, Dieudonné Emmanuel Faculty of Science, Department of Organic Chemistry, University of Yaoundé I, Yaoundé, Cameroon
- Bochet, Christian G. Department Chemie, Universität Fribourg, Fribourg, Switzerland
- Koert, Ulrich Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
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18.08.2018
Published in:
- Natural Product Research. - 2018, vol. 32, no. 16, p. 1971-1976
English
The chemical investigation of the extract of the dried leaves of Rauvolfia caffra (Sond) (synonym Rauvolfia macrophylla) (Apocynaceae) led to isolation of a new glycoside derivative, rauvolfianine (1) as well as six known compounds: oleanolic acid (2), sitosterol-3-O-β-D-glucopyranoside (3), betulinic acid (4), vellosimine (5), sarpagine (6) and D-fructofuranosyl-β-(2→1)-α-D-glucopyranoside (7). Compounds 1, 2, 3, 4 and 7 were evaluated for antitubercular activity. Compounds 1 and 2 were the most active (MIC = 7.8125 and 31.25 μg/mL) towards the Isoniazid resistant strain of Mycobacterium tuberculosis AC45. Their structures and relative stereochemistry were elucidated by spectroscopic methods.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 323325
- DOI 10.1080/14786419.2017.1356832
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307237
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