Journal article
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Against the rules: pressure induced transition from high to reduced order
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Neuhaus, Frederik
Department of Chemistry, University of Fribourg, Switzerland - National Center of Competence in Research in Chemical Biology, Geneva, Switzerland
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Mueller, Dennis
Department of Chemistry, University of Fribourg, Switzerland
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Tanasescu, Radu
Department of Chemistry, University of Fribourg, Switzerland
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Stefaniu, Cristina
Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
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Zaffalon, Pierre-Léonard
Department of Chemistry, University of Fribourg, Switzerland
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Balog, Sandor
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Ishikawa, Takashi
Paul Scherrer Institute (PSI), Villigen PSI, Switzerland
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Reiter, Renate
Department of Experimental Polymer Physics, University of Freiburg, Germany
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Brezesinski, Gerald
Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
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Zumbuehl, Andreas
Department of Chemistry, University of Fribourg, Switzerland - National Center of Competence in Research in Chemical Biology, Geneva, Switzerland
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Published in:
- Soft Matter. - 2018, vol. 14, no. 19, p. 3978–3986
English
Envisioning the next generation of drug delivery nanocontainers requires more in- depth information on the fundamental physical forces at play in bilayer membranes. In order to achieve this, we combine chemical synthesis with physical–chemical analytical methods and probe the relationship between a molecular structure and its biophysical properties. With the aim of increasing the number of hydrogen bond donors compared to natural phospholipids, a phospholipid compound bearing urea moieties has been synthesized. The new molecules form interdigitated bilayers in aqueous dispersions and self-assemble at soft interfaces in thin layers with distinctive structural order. At lower temperatures, endothermic and exothermic transitions are observed during compression. The LC1 phase is dominated by an intermolecular hydrogen bond network of the urea moieties leading to a very high chain tilt of 52°. During compression and at higher temperatures, presumably this hydrogen bond network is broken allowing a much lower chain tilt of 35°. The extremely different monolayer thicknesses violate the two-dimensional Clausius–Clapeyron equation.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Chemistry
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/307126
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