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Against the rules: pressure induced transition from high to reduced order

  • Neuhaus, Frederik Department of Chemistry, University of Fribourg, Switzerland - National Center of Competence in Research in Chemical Biology, Geneva, Switzerland
  • Mueller, Dennis Department of Chemistry, University of Fribourg, Switzerland
  • Tanasescu, Radu Department of Chemistry, University of Fribourg, Switzerland
  • Stefaniu, Cristina Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
  • Zaffalon, Pierre-Léonard Department of Chemistry, University of Fribourg, Switzerland
  • Balog, Sandor Adolphe Merkle Institute, University of Fribourg, Switzerland
  • Ishikawa, Takashi Paul Scherrer Institute (PSI), Villigen PSI, Switzerland
  • Reiter, Renate Department of Experimental Polymer Physics, University of Freiburg, Germany
  • Brezesinski, Gerald Max Planck Institute of Colloids and Interfaces, Research Campus Potsdam-Golm, Germany
  • Zumbuehl, Andreas Department of Chemistry, University of Fribourg, Switzerland - National Center of Competence in Research in Chemical Biology, Geneva, Switzerland
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    03.05.2018
Published in:
  • Soft Matter. - 2018, vol. 14, no. 19, p. 3978–3986
English Envisioning the next generation of drug delivery nanocontainers requires more in- depth information on the fundamental physical forces at play in bilayer membranes. In order to achieve this, we combine chemical synthesis with physical–chemical analytical methods and probe the relationship between a molecular structure and its biophysical properties. With the aim of increasing the number of hydrogen bond donors compared to natural phospholipids, a phospholipid compound bearing urea moieties has been synthesized. The new molecules form interdigitated bilayers in aqueous dispersions and self-assemble at soft interfaces in thin layers with distinctive structural order. At lower temperatures, endothermic and exothermic transitions are observed during compression. The LC1 phase is dominated by an intermolecular hydrogen bond network of the urea moieties leading to a very high chain tilt of 52°. During compression and at higher temperatures, presumably this hydrogen bond network is broken allowing a much lower chain tilt of 35°. The extremely different monolayer thicknesses violate the two-dimensional Clausius–Clapeyron equation.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/307126
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