Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers
- Bielmann, Andreas Spiez Laboratory, Spiez, Switzerland - University of Fribourg, Departement of Chemistry, Switzerland
- Sambiagio, Nicolas Spiez Laboratory, Spiez, Switzerland - École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Switzerland
- Wehr, Nathalie Spiez Laboratory, Spiez, Switzerland - University of Fribourg, Departement of Chemistry, Switzerland
- Gerber-Lemaire, Sandrine École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Switzerland
- Bochet, Christian G. University of Fribourg, Departement of Chemistry, Switzerland
- Curty, Christophe Spiez Laboratory, Spiez, Switzerland
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27.06.2018
Published in:
- RSC Advances. - 2018, vol. 8, no. 42, p. 23881–23890
English
Sulfur Mustard (SM) is a blistering agent used as a chemical weapon. Glutathione (GSH) is involved in the β-lyase degradation pathway of SM and recently, bioadducts between SM and GSH were observed in vitro. While these bioadducts have never been isolated from in vivo tests or real poisoning with SM, they could be of interest as potential future biomarkers for the retrospective validation of exposure. We herein report the synthesis of different observed and new potential GSH–SM bioadducts as reference materials for analytical investigation. Two distinct approaches were investigated: a building-block pathway and the direct reaction with GSH. The availability of these references will aid future studies and may lead to the discovery of new GSH–SM biomarkers.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 322843
- DOI 10.1039/C8RA03360A
- Persistent URL
- https://folia.unifr.ch/unifr/documents/307106
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