Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers

Bielmann, Andreas; Sambiagio, Nicolas; Wehr, Nathalie; Gerber-Lemaire, Sandrine; Bochet, Christian G.; Curty, Christophe

doi:10.1039/C8RA03360A

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Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers

Bielmann, Andreas Spiez Laboratory, Spiez, Switzerland - University of Fribourg, Departement of Chemistry, Switzerland
Sambiagio, Nicolas Spiez Laboratory, Spiez, Switzerland - École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Switzerland
Wehr, Nathalie Spiez Laboratory, Spiez, Switzerland - University of Fribourg, Departement of Chemistry, Switzerland
Gerber-Lemaire, Sandrine École Polytechnique Fédérale de Lausanne, Institute of Chemical Sciences and Engineering, Switzerland
Bochet, Christian G. University of Fribourg, Departement of Chemistry, Switzerland
Curty, Christophe Spiez Laboratory, Spiez, Switzerland

27.06.2018

Published in:

RSC Advances. - 2018, vol. 8, no. 42, p. 23881–23890

English Sulfur Mustard (SM) is a blistering agent used as a chemical weapon. Glutathione (GSH) is involved in the β-lyase degradation pathway of SM and recently, bioadducts between SM and GSH were observed in vitro. While these bioadducts have never been isolated from in vivo tests or real poisoning with SM, they could be of interest as potential future biomarkers for the retrospective validation of exposure. We herein report the synthesis of different observed and new potential GSH–SM bioadducts as reference materials for analytical investigation. Two distinct approaches were investigated: a building-block pathway and the direct reaction with GSH. The availability of these references will aid future studies and may lead to the discovery of new GSH–SM biomarkers.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language