Regulation of calretinin in malignant mesothelioma is mediated by septin 7 binding to the CALB2 promoter
- Blum, Walter Anatomy, Department of Medicine, University of Fribourg, Switzerland
- Pecze, László Anatomy, Department of Medicine, University of Fribourg, Switzerland
- Wörthmüller Rodriguez, Janine Anatomy, Department of Medicine, University of Fribourg, Switzerland
- Steinauer, Martine Anatomy, Department of Medicine, University of Fribourg, Switzerland
- Schwaller, Beat Anatomy, Department of Medicine, University of Fribourg, Switzerland
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27.04.2018
Published in:
- BMC Cancer. - 2018, vol. 18, p. 475
English
The calcium-binding protein calretinin (gene name: CALB2) is currently considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma (MM). MM is a very aggressive tumor strongly linked to asbestos exposure and with no existing cure so far. The mechanisms of calretinin regulation, as well as its distinct function in MM are still poorly understood.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 309530
- DOI 10.1186/s12885-018-4385-7
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306773
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