Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

Wu, Licun; Blum, Walter; Zhu, Chang-Qi; Yun, Zhihong; Pecze, László; Kohno, Mikihiro; Chan, Mei-Lin; Zhao, Yidan; Felley-Bosco, Emanuela; Schwaller, Beat; Perrot, Marc de

doi:10.1186/s12885-018-4354-1

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Journal article

Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma

Wu, Licun Division of Thoracic Surgery, University Health Network, Toronto, Canada - Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
Blum, Walter Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland - INSERM, U1162, Paris, France
Zhu, Chang-Qi Princess Margaret Cancer Centre, University Health Network, Toronto, Canada
Yun, Zhihong Division of Thoracic Surgery, University Health Network, Toronto, Canada
Pecze, László Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
Kohno, Mikihiro Division of Thoracic Surgery, University Health Network, Toronto, Canada
Chan, Mei-Lin Division of Thoracic Surgery, University Health Network, Toronto, Canada
Zhao, Yidan Division of Thoracic Surgery, University Health Network, Toronto, Canada
Felley-Bosco, Emanuela Laboratory of Molecular Oncology, University Hospital Zurich, Switzerland
Schwaller, Beat Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
Perrot, Marc de Division of Thoracic Surgery, University Health Network, Toronto, Canada - Princess Margaret Cancer Centre, University Health Network, Toronto, Canada - Division of Thoracic Surgery, Toronto General Hospital, Canada

27.04.2018

Published in:

BMC Cancer. - 2018, vol. 18, p. 471

English Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target therapies against MSC to improve the efficacy of treatment in malignant mesothelioma.

Faculty

Faculté des sciences et de médecine

Department

Département de Médecine

Language