Journal article

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How asbestos drives the tissue towards tumors: YAP activation, macrophage and mesothelial precursor recruitment, RNA editing, and somatic mutations

  • Rehrauer, Hubert Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Switzerland
  • Wu, Licun Latner Thoracic Surgery Research Laboratories, University of Toronto, Canada
  • Blum, Walter Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Pecze, László Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Henzi, Thomas Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Serre-Beinier, Véronique Department of Thoracic Surgery, University Hospitals of Geneva, Switzerland
  • Aquino, Catherine Functional Genomics Center Zurich, ETH Zurich and University of Zurich, Switzerland
  • Vrugt, Bart Institute of Surgical Pathology, University Hospital Zurich, Switzerland
  • Perrot, Marc de Laboratory of Molecular Oncology, University Hospital Zürich, Switzerland
  • Schwaller, Beat Department of Medicine, Unit of Anatomy, University of Fribourg, Switzerland
  • Felley-Bosco, Emanuela Laboratory of Molecular Oncology, University Hospital Zürich, Switzerland
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    05.03.2018
Published in:
  • Oncogene. - 2018, vol. 37, no. 20, p. 2645–2659
English Chronic exposure to intraperitoneal asbestos triggered a marked response in the mesothelium well before tumor development. Macrophages, mesothelial precursor cells, cytokines, and growth factors accumulated in the peritoneal lavage. Transcriptome profiling revealed YAP/TAZ activation in inflamed mesothelium with further activation in tumors, paralleled by increased levels of cells with nuclear YAP/TAZ. Arg1 was one of the highest upregulated genes in inflamed tissue and tumor. Inflamed tissue showed increased levels of single-nucleotide variations, with an RNA-editing signature, which were even higher in the tumor samples. Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naïve mice supporting the role of the environment in tumor progression.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/306750
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