Potential biomarkers of Parkinson’s disease revealed by plasma metabolic profiling
- Zhao, Huiyuan CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
- Wang, Cui Department of Neurology, Dalian Central Hospital, Dalian, China
- Zhao, Nan CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
- Li, Wenxue Department of Medicine, University of Fribourg, Switzerland
- Yang, Zhaofei Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China
- Liu, Xinxin CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
- Le, Weidong Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital of Dalian Medical University, Dalian, China
- Zhang, Xiaozhe CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
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01.04.2018
Published in:
- Journal of Chromatography B. - 2018, vol. 1081–1082, p. 101–108
English
The plasma of Parkinson's disease (PD) patients may contain various altered metabolites associated with the risk or progression of the disease. Characterization of the abnormal metabolic pattern in PD plasma is therefore critical for the search for potential PD biomarkers. We collected blood plasma samples from PD patients and used an LC-MS based metabolomics approach to identify 17 metabolites with significantly altered levels. Metabolic network analysis was performed to place the metabolites linked to different pathways. The metabolic pathways involved were associated with tyrosine biosynthesis, glycerol phospholipid metabolism, carnitine metabolism and bile acid biosynthesis, within which carnitine and bile acid metabolites as potential biomarkers are first time reported. These abnormal metabolic changes in the plasma of patients with PD were mainly related to lipid metabolism and mitochondrial function.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 309522
- DOI 10.1016/j.jchromb.2018.01.025
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306693
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