Perspective: cardiovascular responses to sugar-sweetened beverages in humans: a narrative review with potential hemodynamic mechanisms
- Monnard, Cathriona R. Department of Medicine/Physiology, University of Fribourg, Switzerland
- Grasser, Erik Konrad Department of Medicine/Physiology, University of Fribourg, Switzerland
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01.03.2018
Published in:
- Advances in Nutrition. - 2018, vol. 9, no. 2, p. 70–77
English
Cardiovascular diseases are still the primary cause of mortality worldwide, with high blood pressure and type 2 diabetes as major promoters. Over the past 3 decades, almost in parallel with the rise in cardiovascular disease incidence, the consumption of sugar-sweetened beverages (SSBs) has increased. In this context, SSBs are potential contributors to weight gain and increase the risk for elevations in blood pressure, type 2 diabetes, coronary heart disease, and stroke. Nevertheless, the mechanisms underlying the cardiovascular and metabolic responses to SSBs, in particular on blood pressure, are poorly understood. We discuss and propose potential mechanisms underlying differential effects of sugars on postprandial blood pressure regulation; provide evidence for additional molecular contributors, i.e., fibroblast growth factor 21, towards sugar-induced cardiovascular responses; and discuss potential cardiovascular neutral sugars. Furthermore, we explore whether pre-existing glucose intolerance in humans exacerbates the cardiovascular responses to SSBs, thus potentially aggravating the cardiovascular risk in already-susceptible individuals.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 309520
- DOI 10.1093/advances/nmx023
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306679
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