Journal article
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Synthesis and biophysical characterization of an odd-numbered 1,3-diamidophospholipid
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Neuhaus, Frederik
Department of Chemistry, University of Fribourg, Switzerland - National Centre of Competence in Research in Chemical Biology, Geneva, Switzerland
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Mueller, Dennis
Department of Chemistry, University of Fribourg, Switzerland
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Tanasescu, Radu
Department of Chemistry, University of Fribourg, Switzerland
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Balog, Sandor
Adolphe Merkle Institute, University of Fribourg, Switzerland
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Takashi Ishikawa
Paul Scherrer Institute (PSI), OFLB/010, Villigen PSI, Switzerland
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Brezesinski, Gerald
Max Planck Institute of Colloids and Interfaces, Research Campus, Potsdam, Germany
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Zumbuehl, Andreas
Department of Chemistry, University of Fribourg, Switzerland - National Centre of Competence in Research in Chemical Biology, Geneva, Switzerland
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Published in:
- Langmuir. - 2018, vol. 34, no. 10, p. 3215–3220
English
Nanomedicine suffers from low drug delivery efficiencies. Mechanoresponsive vesicles could provide an alternative way to release active compounds triggered by the basic physics of the human body. 1,3-Diamidophospholipids with C16 tails proved to be an effective building block for mechanoresponsive vesicles, but their low main phase transition temperature prevents an effective application in humans. As the main phase transition temperature of a membrane depends on the fatty acyl chain length, we synthesized a C17 homologue of a 1,3-diamidophospholipid: Rad-PC-Rad. The elevated main phase transition temperature of Rad-PC-Rad allows mechanoresponsive drug delivery at body temperature. Herein, we report the biophysical properties of Rad-PC-Rad monolayer and bilayer membranes. Rad-PC- Rad is an ideal candidate for advancing the concept of physically triggered drug release.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Chemistry
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/306549
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