Journal article

Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts

  • Aurore, Valerie Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Caldana, Fabienne Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Blanchard, Marianne Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Kharoubi-Hess, Solange Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Lannes, Nils Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Mantel, Pierre-Yves Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Filgueira, Luis Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
  • Walch, Michael Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
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    01.02.2018
Published in:
  • Nanomedicine: Nanotechnology, Biology and Medicine. - 2018, vol. 14, no. 2, p. 601–607
English Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its bactericidal activity. Here, we investigated the bactericidal effects of nano-silver particles in bacteria infected human osteoclasts. We found that nano-silver in per se non-toxic concentration enhanced the bactericidal activity in osteoclasts against intracellular Methicillin-resistant, virulent Staphylococcus aureus. The reduced bacterial survival in nano-silver pretreated cells correlated with increased reactive oxygen responses towards the invading pathogens. Overall, these results indicate that nano-silver compounds should be considered as an effective treatment and prevention option for bacterial bone and orthopedic implant infections.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/306507
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