Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts
- Aurore, Valerie Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Caldana, Fabienne Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Blanchard, Marianne Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Kharoubi-Hess, Solange Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Lannes, Nils Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Mantel, Pierre-Yves Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Filgueira, Luis Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
- Walch, Michael Anatomy unit, Department of Medicine, University of Fribourg, Fribourg, Switzerland
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01.02.2018
Published in:
- Nanomedicine: Nanotechnology, Biology and Medicine. - 2018, vol. 14, no. 2, p. 601–607
English
Bone infections are difficult to treat and can lead to severe tissue destruction. Acute bone infections are usually caused by Staphylococcus aureus. Osteoclasts, which belong to the monocyte/macrophage lineage, are the key cells in bone infections. They are not well equipped for killing bacteria and may serve as a reservoir for bacterial pathogens. Silver has been known for centuries for its bactericidal activity. Here, we investigated the bactericidal effects of nano-silver particles in bacteria infected human osteoclasts. We found that nano-silver in per se non-toxic concentration enhanced the bactericidal activity in osteoclasts against intracellular Methicillin-resistant, virulent Staphylococcus aureus. The reduced bacterial survival in nano-silver pretreated cells correlated with increased reactive oxygen responses towards the invading pathogens. Overall, these results indicate that nano-silver compounds should be considered as an effective treatment and prevention option for bacterial bone and orthopedic implant infections.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 309042
- DOI 10.1016/j.nano.2017.11.006
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306507
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