Chromatin-remodeling enzymes in control of Schwann cell development, maintenance and plasticity
- Jacob, Claire Department of Biology, University of Fribourg, Switzerland
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01.12.2017
Published in:
- Current Opinion in Neurobiology. - 2017, vol. 47, p. 24–30
English
Gene regulation is essential for cellular differentiation and plasticity. Schwann cells (SCs), the myelinating glia of the peripheral nervous system (PNS), develop from neural crest cells to mature myelinating SCs and can at early developmental stage differentiate into various cell types. After a PNS lesion, SCs can also convert into repair cells that guide and stimulate axonal regrowth, and remyelinate regenerated axons. What controls their development and versatile nature? Several recent studies highlight the key roles of chromatin modifiers in these processes, allowing SCs to regulate their gene expression profile and thereby acquire or change their identity and quickly react to their environment.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 306705
- DOI 10.1016/j.conb.2017.08.007
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306307
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