In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

Evina, Jean Noel; Ngono Bikobo, Dominique Serge; Zintchem, Auguste Abouem A.; Mbabi Nyemeck II, Norbert; Moni Ndedi, Esther Del Florence; Betote Diboué, Patrick Hervé; Nyegue, Maximilienne Ascension; Atchadé, Alex de Théodore; Pegnyemb, Dieudonné Emmanuel; Koert, Ulrich; Bochet, Christian G.

doi:10.1016/j.bjp.2017.09.006

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In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

Evina, Jean Noel Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
Ngono Bikobo, Dominique Serge Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Department Chemie, Universität Fribourg, Switzerland
Zintchem, Auguste Abouem A. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Department of Chemistry, Higher Training College, University of Yaoundé I, Cameroon
Mbabi Nyemeck II, Norbert Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Faculty of Chemistry, Philipps-Universität Marburg, Germany
Moni Ndedi, Esther Del Florence Department of Microbiology, Faculty of Science, University of Yaoundé I, Cameroon
Betote Diboué, Patrick Hervé Department of Microbiology, Faculty of Science, University of Yaoundé I, Cameroon
Nyegue, Maximilienne Ascension Department of Microbiology, Faculty of Science, University of Yaoundé I, Cameroon
Atchadé, Alex de Théodore Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
Pegnyemb, Dieudonné Emmanuel Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Cameroon
Koert, Ulrich Faculty of Chemistry, Philipps-Universität Marburg, Germany
Bochet, Christian G. Department Chemie, Universität Fribourg, Switzerland

01.11.2017

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Revista Brasileira de Farmacognosia. - 2017, vol. 27, no. 6, p. 739-743

English A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β- glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-d-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6″- O-acetylvitexin, quercetin 3-O-β-d-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-d-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125μg/ml.

Faculty

Faculté des sciences et de médecine

Department

Département de Chimie

Language