Journal article
+ 1 other files
Disturbed processing of contextual information in HCN3 channel deficient mice
-
Stieglitz, Marc S.
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Fenske, Stefanie
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Hammelmann, Verena
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Becirovic, Elvir
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Schöttle, Verena
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Delorme, James E.
Neurobiochemistry of Circadian Rhythms, Department of Biology, University of Fribourg, Switzerland
-
Schöll-Weidinger, Martha
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Mader, Robert
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Deussing, Jan
Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany
-
Wolfer, David P.
Institute of Anatomy, University of Zurich, Switzerland - Department of Health Sciences and Technology, Institute of Human Movement Sciences and Sport, ETH Zurich, Switzerland - Neuroscience Center Zurich, University of Zurich and ETH Zurich, Switzerland
-
Seeliger, Mathias W.
Ocular Neurodegeneration Research Group, Centre for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University Tuebingen, Germany
-
Albrecht, Urs
Neurobiochemistry of Circadian Rhythms, Department of Biology, University of Fribourg, Switzerland
-
Wotjak, Carsten T.
Department of Stress Neurobiology and Neurogenetics, Max Planck Institute of Psychiatry, Munich, Germany
-
Biel, Martin
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Michalakis, Stylianos
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
-
Wahl-Schott, Christian
Center for Integrated Protein Science and Center for Drug Research, Department of Pharmacy, Ludwig-Maximilians University, Munich, Germany
Show more…
Published in:
- Frontiers in Molecular Neuroscience. - 2018, vol. 10, p. 436
English
Hyperpolarization-activated cyclic nucleotide-gated channels (HCNs) in the nervous system are implicated in a variety of neuronal functions including learning and memory, regulation of vigilance states and pain. Dysfunctions or genetic loss of these channels have been shown to cause human diseases such as epilepsy, depression, schizophrenia, and Parkinson's disease. The physiological functions of HCN1 and HCN2 channels in the nervous system have been analyzed using genetic knockout mouse models. By contrast, there are no such genetic studies for HCN3 channels so far. Here, we use a HCN3-deficient (HCN3−/−) mouse line, which has been previously generated in our group to examine the expression and function of this channel in the CNS. Specifically, we investigate the role of HCN3 channels for the regulation of circadian rhythm and for the determination of behavior. Contrary to previous suggestions we find that HCN3−/− mice show normal visual, photic, and non-photic circadian function. In addition, HCN3−/− mice are impaired in processing contextual information, which is characterized by attenuated long-term extinction of contextual fear and increased fear to a neutral context upon repeated exposure.
-
Faculty
- Faculté des sciences et de médecine
-
Department
- Département de Biologie
-
Language
-
-
Classification
-
Biological sciences
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/306223
Other files
Statistics
Document views: 49
File downloads:
- alb_dpc.pdf: 64
- alb_dpc_sm.pdf: 58