Journal article

High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal

  • Kieffer, Nicolas Université de Fribourg, Fribourg, Switzerland
  • Aires-de-Sousa, Marta Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisbon, Portugal
  • Nordmann, Patrice Université de Fribourg, Fribourg, Switzerland - University of Lausanne and University Hospital Centre, Lausanne, Switzerland
  • Poirel, Laurent Université de Fribourg, Fribourg, Switzerland
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  • Emerging Infectious Diseases. - 2017, vol. 23, no. 12, p. 2023–2029
English The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
Faculté des sciences et de médecine
Médecine 3ème année
  • English
Biological sciences
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