High Rate of MCR-1–Producing Escherichia coli and Klebsiella pneumoniae among Pigs, Portugal
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Kieffer, Nicolas
Université de Fribourg, Fribourg, Switzerland
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Aires-de-Sousa, Marta
Escola Superior de Saúde da Cruz Vermelha Portuguesa, Lisbon, Portugal
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Nordmann, Patrice
Université de Fribourg, Fribourg, Switzerland - University of Lausanne and University Hospital Centre, Lausanne, Switzerland
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Poirel, Laurent
Université de Fribourg, Fribourg, Switzerland
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Published in:
- Emerging Infectious Diseases. - 2017, vol. 23, no. 12, p. 2023–2029
English
The mcr-1 (mobile colistin resistance 1) gene, which encodes phosphoethanolamine transferase, has been recently identified as a source of acquired resistance to polymyxins in Escherichia coli. Using the SuperPolymyxin selective medium, we prospectively screened 100 pigs at 2 farms in Portugal for polymyxin-resistant Enterobacteriaceae and recovered 98 plasmid-mediated MCR-1–producing isolates. Most isolates corresponded to nonclonally related E. coli belonging to many sequence types; we also found 2 Klebsiella pneumoniae sequence types. The mcr-1 gene was carried on IncHI2 or IncP plasmid backbones. Our finding of a high rate of MCR-1 producers on 2 pig farms in Portugal highlights the diffusion of that colistin-resistance determinant at the farm level. The fact that the pigs received colistin as metaphylaxis in their feed during the 6 weeks before sampling suggests selective pressure.
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine 3ème année
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Language
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Classification
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Biological sciences
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/306219
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