Biodistribution of single and aggregated gold nanoparticles exposed to the human lung epithelial tissue barrier at the air-liquid interface
- Durantie, Estelle BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Vanhecke, Dimitri BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Rodriguez-Lorenzo, Laura BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Delhaes, Flavien BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Balog, Sandor BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Septiadi, Dedy BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Bourquin, Joel BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
- Petri-Fink, Alke BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland - Chemistry Department, University of Fribourg, Switzerland
- Rothen-Rutishauser, Barbara BioNanomaterials Group, Adolphe Merkle Institute, Université de Fribourg, Switzerland
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29.11.2017
Published in:
- Particle and Fibre Toxicology. - 2017, vol. 14, p. 49
English
The lung represents the primary entry route for airborne particles into the human body. Most studies addressed possible adverse effects using single (nano)particles, but aerosolic nanoparticles (NPs) tend to aggregate and form structures of several hundreds nm in diameter, changing the physico-chemical properties and interaction with cells. Our aim was to investigate how aggregation might affect the biodistribution; cellular uptake and translocation over time of aerosolized NPs at the air-blood barrier interface using a multicellular lung system.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 306229
- DOI 10.1186/s12989-017-0231-3
- Persistent URL
- https://folia.unifr.ch/unifr/documents/306165
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