Journal article
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A new procyanidin B from Campylospermum zenkeri (Ochnaceae) and antiplasmodial activity of two derivatives of (±)-serotobenine
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Mbabi Nyemeck II, Norbert
Department of Organic chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
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Ngono Bikobo, Dominique Serge
Department of Organic chemistry, Faculty of Science, University of Yaoundé I, Cameroon
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Zintchem, Auguste Abouem A.
Department of Organic chemistry, Faculty of Science, University of Yaoundé I, Cameroon - Department of Chemistry, Higher Training College, University of Yaoundé I, Yaoundé, Cameroon
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Schäfer, Eva-Maria
Institut für pharmazeutische Chemie, Philipps- Universität Marburg, Marburg, Germany
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Bochet, Christian G.
Department Chemie, Universität Fribourg, Switzerland
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Pegnyemb, Dieudonné Emmanuel
Department of Organic chemistry, Faculty of Science, University of Yaoundé I, Cameroon
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Koert, Ulrich
Faculty of Chemistry, Philipps-Universität Marburg, Marburg, Germany
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Published in:
- Natural Product Research. - 2017, vol. 31, no. 24, p. 2875-2884
English
Phytochemical investigation of the stem bark of Campylospermum zenkeri led to the isolation of five known compounds: (Z,Z)-9,12-octadecadienoic acid (1), serotobenine (2), agathisflavone (3), lophirone A (4) and lophirone F (5), together with a new derivative of procyanidin B, a catechin dimer named zenkerinol (6). Serotobenine (2) is structurally related to decursivine which shows moderate activity against D6 and W2 strains of Plasmodium falciparum. For a better understanding of structure-activity relationships, three new semi-synthetic derivatives of serotobenine (2) have been prepared. These are: serotobenine monopropionate (2a), serotobenine monopivalate (2b) and serotobenine cyclohexyl ether (2c) respectively. Two of them (2a) and (2b), were evaluated for their antiplasmodial activity against P. falciparum 3D7 strain in a parasite lactate-dehydrogenase (pLDH) assay. Compound 2b was more active than compound 2a based on their IC50 values (36.6 and 123 μM, respectively).
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Chimie
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Language
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Classification
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Analytical chemistry
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/306141
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