High-level resistance to colistin mediated by various mutations in the crrb gene among carbapenemase-producing klebsiella pneumoniae
-
Jayol, Aurélie
Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA Paris, IAME, France), University of Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, University of Fribourg, Switzerland - Laboratory of Bacteriology, Bordeaux University Hospital, Bordeaux, France - CNRS UMR5234, University of Bordeaux, France
-
Nordmann, Patrice
Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA Paris, IAME, France), University of Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, University of Fribourg, Switzerland - University of Lausanne and University Hospital Center, Lausanne, Switzerland
-
Brink, Adrian
Department of Clinical Microbiology, Ampath National Laboratory Services, Milpark Hospital, Johannesburg, South Africa
-
Villegas, Maria-Virginia
International Center for Medical Research and Training, CIDEIM, Cali, Colombia
-
Dubois, Véronique
Laboratory of Bacteriology, Bordeaux University Hospital, Bordeaux, France - CNRS UMR5234, University of Bordeaux, France
-
Poirel, Laurent
Emerging Antibiotic Resistance Unit, Medical and Molecular Microbiology, Department of Medicine, University of Fribourg, Switzerland - INSERM European Unit (LEA Paris, IAME, France), University of Fribourg, Switzerland - National Reference Center for Emerging Antibiotic Resistance, University of Fribourg, Switzerland
Show more…
Published in:
- Antimicrobial Agents and Chemotherapy. - 2017, vol. 61, no. 11, p. e01423-17
English
Mutations in crrAB genes encoding a two-component regulator involved in modifications of lipopolysaccharide were searched for among a collection of colistin- resistant Klebsiella pneumoniae isolates. Four isolates, respectively, producing carbapenemases NDM-1, OXA-181, or KPC-2 showed mutated CrrB proteins compared with those in wild-type strains. Complementation assays with a wild-type CrrB protein restored the susceptibility to colistin in all cases, confirming the involvement of the identified substitutions in the resistance phenotype.
-
Faculty
- Faculté des sciences et de médecine
-
Department
- Médecine 3ème année
-
Language
-
-
Classification
-
Biological sciences
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/306106
Statistics
Document views: 35
File downloads: