Photochemical C–H activation: generation of indole and carbazole libraries, and first total synthesis of clausenawalline D
- Alimi, Isak Department of Chemistry, University of Fribourg, Switzerland
- Remy, Richard Department of Chemistry, University of Fribourg, Switzerland
- Bochet, Christian G. Department of Chemistry, University of Fribourg, Switzerland
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16.06.2017
Published in:
- European Journal of Organic Chemistry. - 2017, vol. 2017, no. 22, p. 3197–3210
English
The photolysis of N-aryltriazoles and N-arylbenzotriazoles leads to indoles and carbazoles, respectively. Because libraries of triazoles can be accessed rapidly, for example by the copper-catalyzed [3+2] cycloaddition reaction between alkynes and azides, this reaction allows the preparation of indoles in a single operation, by the simultaneous photolysis of the precursor library. As an example of such a synthesis of carbazoles, we prepared for the first time clausenawalline D, an antimalarial alkaloid that was recently isolated.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 305048
- DOI 10.1002/ejoc.201700300
- Persistent URL
- https://folia.unifr.ch/unifr/documents/305979
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